XOMA Corporation (Nasdaq:XOMA) reported its partner Les Laboratoires Servier (Servier) and the Company have entered into an agreement with Boehringer Ingelheim to transfer XOMA's technology and process for the commercial manufacture of gevokizumab, XOMA's novel interleukin 1-beta (IL-1beta) allosteric modulating antibody.
Gevokizumab currently is in Phase 3 clinical development in patients with non-infectious uveitis (NIU) involving the intermediate and/or posterior segment of the eye. The global development plan includes a Phase 3 trial to be conducted by Servier in patients with Behcet's uveitis.
Upon completion of the transfer and the establishment of biological comparability, Boehringer Ingelheim is expected to produce gevokizumab at its facility in Biberach, Germany, for XOMA's commercial use. XOMA and Servier retain all rights to the development and commercialization of gevokizumab. Financial terms of the agreement were not disclosed.
Endocyte, Inc. (Nasdaq:ECYT), a biopharmaceutical company developing targeted small molecule drug conjugates (SMDCs) and companion imaging diagnostics for personalized therapy, reported that Endocyte's approach of utilizing a SMDC targeted to the folate receptor (FR) may provide a promising treatment for patients with autosomal-dominant polycystic kidney disease (ADPKD).
In a mouse model of polycystic kidney disease (PKD), treatment with a folate-conjugated form of rapamycin, FC-rapa, (EC0371) strongly attenuated proliferation and growth of renal cysts and preserved renal function.
The results were published online ahead of print in the Journal of the American Society of Nephrology and will be available in print in the October issue.
CRWE launched CRWE Real Estate to provide a global portal for property listings at a fee of only $1 a day. CRWE Real Estate mission is to empower consumers with information and tools to make smart decisions about homes, real estate and mortgages. CRWE Direct is an online business-to-business marketplace for manufacturers and small to large businesses to purchase various types of merchandise. Manufacturers may start downloading their product immediately, free of charge during the next six months. Thereafter, there will be various annual fees. The listing process and image loading for both sites are user-friendly.
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Capstone Turbine Corporation (Nasdaq:CPST), the world's leading clean technology manufacturer of microturbine energy systems, reported the sale of five low-emission C65 Capstone microturbines to a Fortune 100 oil conglomerate in Thailand. The microturbines will be the prime power source for a remote natural gas pipeline station and nearby village that both are completely isolated from the utility grid.
The C65 microturbines will run on pipeline gas and supply prime power to the onshore transmission station, which receives natural gas from two offshore gas fields up to 200 kilometers (124 miles) away in the Andaman Sea. Approximately 120-kilowatts of microturbine power will be used by villagers
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